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A cardinal feature of human brain development is that sensory, cognitive and emotional experiences shape synapses and neural-circuit development.

These features are alterations in various Intellectual Disability (ID) and
Autism Spectrum Disorder (ASD).

Neurobiology of syngap1 in synaptic function and Intellectual Disability

A cardinal feature of human brain development is that sensory, cognitive and emotional experiences shape synapses and neural-circuit development. These features are alterations in various Intellectual Disability (ID) and Autism Spectrum Disorder (ASD). Mutations that cause ID and ASD have been discovered increasingly in genes that encode for proteins that regulate synaptic function and/or structure. By using syngap1 as a model, we will study how mutations in genes sich as syngap1 impacts synaptic structure, function and maturation, particualrly during early stages of development.