Introduction

Chromatin remodeling is an important event in the eukaryotic nucleus rendering nucleosomal DNA accessible for various transaction processes. The dynamic nature of chromatin is facilitated by Remodeling Factors through participation of the collective action of (a) ATP and (b) Non-ATP dependent factors. Considering the importance of these factors in mammals and eukaryotes, 'CREMOFAC', a dedicated and frequently updated web-database for chromatin remodeling factors has been developed.

The database harbors 64 types of remodeling factors from 49 different organisms reported in literature and facilitates a comprehensive search for them. In addition, it also provides in-depth information for the factors reported in the three widely studied mammals namely, human, mouse and rat. Further, information on literature, pathways, and phylogenetic relationships has also been covered.

The 'Simple and Advanced Search' feature can be used to search the database through various possible queries to extract useful data. The 'Download Database' section provides for convenient downloading of a large number of the chromatin remodeling protein sequences in various organisms while the 'Phylogeny Trees' feature highlights the phylogenetic relationship among various organisms for a given factor.


Cremofac is a freely accessible and downloadable database. For any further queries, mail to shipra@jncasr.ac.in or mrsrao@jncasr.ac.in.