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Molecular Parasitology and
Protein Engineering
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| Our lab studies hypoxanthine guanine phosphoribosyltransferase and adenylosuccinate synthetase, enzymes involved in purine salvage in the malarial parasite, Plasmodium falciparum. We have also been studying enzymes involved in hemoglobin degradation and glycolysis. Enzymes of these essential pathways are of interest as targets for antimalarial chemotherapy. Protein engineering/ mutagenesis, spectroscopy and X- Ray crystallographic techniques are used to probe the structure, function and dynamics of these enzymes. Other aspects studied include substrate specificity,catalytic and kinetic mechanisms, and protein stability. Insights from these studies would aid the development of new antimalarials. |
Prof. .Hemalatha Balaram
Molecular Biology and Genetics Unit
Jawaharlal Nehru Centre for Advanced Scientific Research
Bangalore 560064, India
Ph:91-80-22082812
Fax:91-80-22082766
E-mail: hb@jncasr.ac.in |
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