Research interest of our group at JNCASR



The main focus of our research is towards the development of chemical and nanotechnology based innovative strategies to prevent the spread of infections and the development of new antimicrobial agents for the treatment of infectious diseases. By understanding the basic mechanism of drug resistance, mode of transmission of infections and difficulties associated with systemic delivery of drugs, we have taken the following approaches:


A.  Antimicrobial Therapeutics

The retreat from new antibiotic development by the pharmaceutical companies has exacerbated the challenge of widespread drug resistance. This growing public health problem has spurred renewed efforts in academia to develop novel types of antibacterial agents with mechanisms radically different from existing drugs, or to develop novel strategies for broadening the spectrum of activity of available drugs. Towards these goals we have following specific aims:


B.  Antimicrobial and Antifouling Materials

Antimicrobial and antifouling materials have various applications, including but not limited to surgical equipment and protective apparel in hospitals, medical implants, biosensors, textiles, food packaging and food storage, water purification systems, and marine and industrial equipments. There is an urgent need to develop smart materials incorporating both antimicrobial and antifouling capabilities. The focus of the project is two-fold:


C.  Smart Drug Delivery System

Drug delivery technology represents one of the frontier areas of medicinal research, which involves multidisciplinary scientific approach to combat many deadly diseases including cancer. A large majority of patients die not from the disease but from the side effects of conventional chemotherapy, caused mainly due to non-specific drug distribution in the body. Thus delivery of drugs to specific disease sites is of paramount importance. Our focus is to develop liposomal, polymeric, and dendrimer based nano-vehicles to achieve prolonged, localized and targeted drug interaction with the diseased tissues.