Technologies/Processes/Products Available for Licensing

Many interested industries across the globe are negotiating to license our inventions. Some of the industries have executed non-exclusive licensing agreement for couple of inventions. Listed below are the inventions readily available for licensing.

Sl. No. 1: Use of Hydroxydiphenyl Ether Class of Chemicals, as Exemplified by Triclosan, as an Antimalarial and Identification of Fatty Acid Synthesis as its Target
Applicants: JNCASR and Indian Institute of Science
Inventors: Surolia N, Surolia A
Principal Inventor: Prof. Namita Surolia (Email: surolia@jncasr.ac.in)

Sl. No. 2: Photo Responsive Organic Field Effect Transistor
Inventor: Narayan KS
Email: narayan@jncasr.ac.in

Sl. No. 3: Modulators (Inhibitors/Activators) of Histone Acetyltransferases
Inventors: Kundu TK, Balasubramanyam K, Swaminathan V
Principal Inventor: Tapas Kumar Kundu (Email: tapas@jncasr.ac.in)

Sl. No. 4: Polyisoprenyl Benzophenones as Inhibitors of Histone Acetyl Transferases and Uses Thereof
Inventors: Kundu TK, Balasubramanyam K
Principal Inventor: Tapas Kumar Kundu (Email: tapas@jncasr.ac.in)

Sl. No. 5: Highly Specific Polyclonal Antibodies of Individual Core Histone and Uses Thereof
Inventors: Kundu TK, Kulangara FK, Varier RA, Das C
Principal Inventor: Tapas Kumar Kundu (Email: tapas@jncasr.ac.in)

Sl. No. 6: Derivatives of 3,6-disubstituted 1,2,4-triazolo-1,3,4-thiadiazole, a process and uses thereof
Inventors: Kundu TK, Varier RA, Shivananju N, Basappa, Rangappa KS
Applicants: JNCASR and University of Mysore.
Principal Inventor: Tapas Kumar Kundu (Email: tapas@jncasr.ac.in)

For licensing these inventions please complete the form and submit.

Contact Information:

The Administrative Officer
Jawaharlal Nehru Centre for Advanced Scientific Research
Jakkur, Bangalore 560064, Karnataka, India.

Telephone: 080-23622763
Email: jnc_ipr@jncasr.ac.in

Details of the inventions available for licensing

Sl. No. 1: Use of Hydroxydiphenyl Ether Class of Chemicals, as Exemplified by Triclosan, as an Antimalarial and Identification of Fatty Acid Synthesis as its Target
Applicants: JNCASR and Indian Institute of Science
Inventors: Surolia N, Surolia A
Principal Inventor: Prof. Namita Surolia (Email: surolia@jncasr.ac.in)

This invention reports the use of hydroxydiphenyl ether class of chemicals, as exemplified by triclosan, (2,4,4’-trichloro-2’-hydroxydiphenyl ether), for both treatment and design of therapeutics for treatment of malaria. More specifically, the present invention relates to identification of fatty acid synthesis as target for this compound as well as a key enzyme involved in synthesizing them.

Sl. No. 2: Photo Responsive Organic Field Effect Transistor
Inventor: Narayan KS
Email: narayan@jncasr.ac.in
A polymer-based field effect transistor photosensitive to incident light, which may enhance the transistor's characteristics and controlling parameters of the transistor state. The transistor is comprised of a metal-insulator-semiconductor structure with the insulating and semiconducting layers made of a polymeric media. The semiconducting polymer which also is photoconducting, forms the charge transport layer between the source and drain. The transistor exhibits large photosensitivity indicated by the sizable changes in the drain-source current, by a factor of 100 1000 even at low levels of light with illumination of approximately 1 mlux. The photosensitivity of the transistor is further enhanced with introduction of dilute quantity electron acceptor moieties in the semiconducting polymer matrix. Several applications of the light-responsive polymer-transistor are disclosed, such as use as a logic element and as a backbone of an image sensor.

Sl. No. 3: Modulators (Inhibitors/Activators) of Histone Acetyl Transferases
Inventors: Kundu TK, Balasubramanyam K, Swaminathan V
Principal Inventor: Tapas Kumar Kundu (Email: tapas@jncasr.ac.in)

This invention reports that, Anacardic Acid as the first known natural HAT (Histone acetyl transferases) inhibitor and the CTPB as the only known p300 HAT activity specific small molecule HAT activator. Both Anacardic Acid and CTPB could be excellent academic/research reagents to probe HAT specific chromatin function. CTPB also has potential to be used for therapeutic purposes alternative to HDAC (Histone deacetylases) inhibitors. Couple of Entrepreneurs have executed non-exclusive licensing agreements and are marketing both Anacardic Acid and CTPB as academic reagents.

Sl. No. 4: Polyisoprenyl Benzophenones as Inhibitors of Histone Acetyl Transferases and Uses Thereof
Inventors: Kundu TK, Balasubramanyam K
Principal Inventor: Tapas Kumar Kundu (Email: tapas@jncasr.ac.in)

This invention reports that the Garcinol is a highly cell permeable natural HAT inhibitor. Based on it, p300 specific HAT inhibitor that is non-toxic to human cells has been synthesized. It can also repress HIV multiplication.

Garcinol and its derivatives could be potential academic reagents. The Garcinol non-toxic derivatives could be used as potential anti HIV therapeutics. Many more Garcinol derivatives have been synthesized and are not yet disclosed. However, these are available on pre-patent licensing for marketing as academic reagent and for drug development.

Sl. No. 5: Highly Specific Polyclonal Antibodies of Individual Core Histone and Uses Thereof
Inventors: Kundu TK, Kulangara FK, Varier RA, Das C
Principal Inventor: Tapas Kumar Kundu (Email: tapas@jncasr.ac.in)

This invention reports that these set of polyclonal antibodies raised against core Histones, H2A, H2B, H3 and H4. These antibodies can recognize each core histone very specifically.

These antibodies shall be very useful for academic research like in Chromatin Immuno-Precipitation Assay, Western Blotting, Immuno-Histochemistry Assay, and also for the diagnosis of human diseases related to chromatic modification.

Sl. No. 6: Derivatives of 3,6-Disubstituted 1,2,4-Triazolo-1,3,4-Thiadiazole, a Process and Uses Thereof
Inventors: Kundu TK, Varier RA, Shivananju N, Basappa, Rangappa KS
Applicants: JNCASR and University of Mysore.
Principal Inventor: Tapas Kumar Kundu (Email: tapas@jncasr.ac.in)

This invention reports anti squamus cancer (cervical and oral) specific compounds. The effectiveness of these compounds has been tested in vivo and found to be effective. They are undergoing revalidation.

These compounds have tremendous potential to be used as lead molecules for anti cervical or oral cancer therapeutics.

The inventors are very much interested in developing the drug in collaboration with any potential pharmaceutical industry. In addition, R&D can be pursued involving DST/ DBT/CSIR of Government of India.