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| UNIVERSITY/INSTITUTION | YEAR | POSITION |
| Baylor College of Medicine, USA | 1974-75 | Research Associate |
| Baylor College of Medicine, USA | 1975 - 76 | Instructor |
| Baylor College of Medicine, USA | 1976 - 78 | Assistant Professor |
| Indian Institute of Science, Bangalore | 1978 - 82 | Sr. Research Fellow, IISc |
| Indain Institute of Science, Bangalore | 1982 - 87 | Assistant Professor |
| Indian Institute of Science, Bangalore | 1987 - 91 | Associate Professor |
| Indian Institute of Science, Bangalore | 1991 - 09 | Professor, IISc |
| Indian Institute of Science, Bangalore | 1990 - 93 | Chairman, Centre for Genetic Engineering |
| Baylor College of Medicine, USA | 1983 | Visiting Assistant Professor |
| Baylor College of Medicine, USA | 1986 | Research Associate Professor |
| Harvard Medical School, USA | 1988 - 90 | Visiting Associate Professor |
| Harvard Medical School, USA | 1993 | Visiting Professor |
| Indian Institute of Science, Bangalore | 1998 - 03 | Chairman, Department of Biochemistry |
| Ludwig Institute for Cancer Research, University of California at San Diego, USA | 1998 | Visiting Scientist |
| Indian Institute of Science, Bangalore | 2001 - 03 | Astra Professor |
| Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore | 2003 - till date | President |