A group of Indian scientists led by a team in Bengaluru has, for the first time, developed a mouse model of blood vessel formation — important for development of embryos and tumours alike — which may spur a search for new cancer drugs.
The findings, published in ‘Nature’s Scientific Reports’, help understand ‘Rudhira’ (blood in Sanskrit), a gene essential for taking blood to all parts of the body and formation of blood vessels which is co-opted by tumour cells to multiply and spread.
“Generally, formation of blood vessels is controlled and stops soon after the requirement is met. However, in a tumour, it’s uncontrolled and doesn’t know when to stop,” said Prof Maneesha Inamdar, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) and project lead.
Using mouse genetics tools, Inamdar’s team and collaborators — at RIKEN CDB, Kobe, Japan and the National Centre for Biological Sciences, Bengaluru — engineered a mutation in the DNA such that the mouse could be bred to make embryos deficient of Rudhira. The embryos died halfway through development with a deformed heart and short, tangled and leaky blood vessels.
Read more: Times of India, April 05, 2018, http://toi.in/wekh6Y53/a24gk
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