Jawaharlal Nehru Centre for Advanced Scientific Research
 

Dr. James Chelliah

James Chelliah

Faculty Fellow
The Chelliah Laboratory
Neuroscience Unit (NSU)
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
Bangalore, India.
Telephone : +91-80-2208 2613
                   +91-80-2208 2831 (Lab)
Email :         chelliah@jncasr.ac.in
Website:      http://www.jncasr.ac.in/chelliah/


Research Interests

Neurobiology of syngap1 in synaptic function and Intellectual Disability

A cardinal feature of human brain development is that sensory, cognitive and emotional experiences shape synapses and neural-circuit development. These features are alterations in various Intellectual Disability (ID) and Autism Spectrum Disorder (ASD). Mutations that cause ID and ASD have been discovered increasingly in genes that encode for proteins that regulate synaptic function and/or structure. By using syngap1 as a model, we will study how mutations in genes such as syngap1 impacts synaptic structure, function and maturation, particularly during early stages of development.

Recent Publications

  • SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical period synaptic plasticity. Clement JP, Ozkan ED, Aceti M, Miller CA, Rumbaugh G. Journal of Neuroscience 2013 Jun 19;33(25):10447-52

  • Pathogenic SYNGAP1 mutations impair cognitive development by disrupting the maturation of dendritic spines. Clement JP, Aceti M, Creson TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller B, Wiltgen BJ, Miller CA, Xu X, Rumbaugh G Cell 2012 Nov 09;151(4): 709-23.

  • mGluR1 activity generates persistent, NMDA receptor-dependent, depression of hippocampal pyramidal cell excitability. Clement JP, Randall AD, Brown JB. EJN 2009 May 29:12, 2347-2362.

  • Rats smell in stereo. Raghav R, Clement JP, Bhalla US. Science 2006 Feb 3, 311, (5761)666-670.