Jawaharlal Nehru Centre for Advanced Scientific Research

Sheeba Vasu

Sheeba Vasu

Faculty Fellow
Behavioural Neurogenetics Laboratory
Neuroscience Unit (NSU)
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
Bangalore, India.
Telephone : +91-80-2208 2987 (Office)
                    +91-80-2208 2580 (Lab)
Email :         sheeba@jncasr.ac.in
Website :     http://www.jncasr.ac.in/sheeba/

Research Interests

Neuronal Circuits in Fruitflies

My laboratory studies neuronal circuits that regulate rhythmic behaviours such as locomotor activity, sleep, adult-emergence, feeding and egg-laying in drosophilid flies. Genetic amenability of Drosophila melanogaster enables the manipulation of neuronal circuits in a spatio-temporal fashion. The neuronal network that modulates sleep/wake cycles by integrating circadian (daily) clocks and homeostatic control mechanisms is of interest to us. We also examine the role of temperature sensitive ionchannels dTRPA1 in modulating daily rhythms. We use the circadian neuronal circuit in fruitflies as a model to study progression of neurodegenerative Huntington's disease. We are also interested in studying the interaction between central and peripheral circadian oscillators that may control feeding and metabolic rhythms.

Recent Publications

  • Prabhakaran PM, Sheeba V. Temperature sensitivity of circadian clocks is conserved across Drosophila species melanogaster, malerkotliana and ananassae. Chronobiol Int. 2014 Nov;31(9):1008-16. doi: 10.3109/07420528.2014.941471.

  • Prabhakaran PM, Sheeba V. Simulating natural light and temperature cycles in the laboratory reveals differential effects on activity/rest rhythm of four Drosophilids. J Comp Physiol ANeuroethol Sens Neural Behav Physiol. 2014 Oct;200(10):849-62. doi: 10.1007/s00359-014-0927-x.

  • Prabhakaran PM, De J, Sheeba V. Natural conditions override differences in emergence rhythm among closely related drosophilids. PLoS One. 2013 Dec 11;8(12):e83048. doi: 10.1371/journal.pone.0083048.

  • Prabhakaran PM, Sheeba V. Insights into differential activity patterns of drosophilids under semi-natural conditions. J Exp Biol. 2013 Dec 15;216(Pt 24):4691-702. doi: 10.1242/jeb.092270.

  • Potdar S, Sheeba V. Lessons from sleeping flies: insights from Drosophila melanogaster on the neuronal circuitry and importance of sleep. J Neurogenet. 2013 Jun;27(1-2):23-42. doi: 10.3109/01677063.2013.791692.

  • De J, Varma V, Saha S, Sheeba V, Sharma VK. Significance of activity peaks in fruit flies, Drosophila melanogaster, under seminatural conditions. Proc Natl Acad Sci U S A. 2013 May 28;110(22):8984-9. doi: 10.1073/pnas.1220960110. Epub 2013 May 13.

  • Prabhakaran PM, Sheeba V. Sympatric Drosophilid species melanogaster and ananassae differ in temporal patterns of activity. J Biol Rhythms. 2012 Oct;27(5):365-76.

  • Potdar S, Sheeba V. Large ventral lateral neurons determine the phase of evening activity peak across photoperiods in Drosophila melanogaster. J Biol Rhythms. 2012 Aug;27(4):267-79. doi: 10.1177/0748730412449820.