Jakkur, Bangalore 560 064, India
Phd. from IISc, Dept. of Biochemistry with Prof. MRS Rao. Post-doctoral Research at National Institute of Genetics, JAPAN and The Rockefeller University, New York, USA
The regulation of eukaryotic (human) transcription from chromatin template with special emphasis on diseases is the broad area of research of the Transcription and Disease laboratory. The research topics include- regulation of chromatin-mediated transcription by histone chaperones; role of nonhistone chromatin-proteins in the regulation of chromatin- structure/function and the regulation of p53 function by these nonhistone proteins and the small molecule modulators of histone modifying enzymes (histone acetyltransferases, deacetylases and methyltransferases).
Kumar, P. B. R., Swaminathan, V., Banerjee, S., and Kundu, T. K. 2001. p300- Mediated acetylation of human transcriptional coactivator is inhibited by phosphorylation. J. Biol. Chem. 276 (20), 16804-16809.
Karanam Balasubramanyam, V. Swaminathan, Anupama Ranganathan, and Kundu, T.K. (2003). Small Molecule Modulators of Histone Acetyltransferase p300. J. Biol. Chem. 278, 19134-19140.
Banerjee, S., Kumar, P. B. R. and Kundu, T.K. (2004). General Transcriptional Coactivator PC4 activates p53 function. Mol. Cell. Biol, 24, 2052-62.
Balasubramanyam K, Altaf M, Varier RA, Swaminathan V, Ravindran A, Sadhale PP, Kundu TK. (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem. 279, 33716-26.
Balasubramanyam K, Varier RA, Altaf M, Swaminathan V, Siddappa NB, Ranga U, Kundu TK. (2004) Curcumin, a novel p300/CBP specific inhibitor of acetyltransferase, represses the acetylation of histones/nonhistone proteins and HAT dependent chromatin transcription. J Biol Chem. 279, 51163-71.