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Transcription and Disease Laboratory |
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PC4, a novel nonhistone chromatin associated protien
Histone chaperone activates chromatin transcription in an acetylation dependent manner
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group is working on the mechanism of transcription regulation through chromatin in humans, with special reference to diseases. The present areas of interest are * The regulation of p53 function by nonhistone chromatin associated proteins, * Role of higher order chromatin structure and histone chaperones in transcription regulation, * Functional genomics of transcriptional coactivators, * Small molecule modulators of histone modifying enzymes, which may serve as lead compounds for the treatment of asthma, cardiac hypertrophy, AIDS, and cancer. |
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| Patents |