BIOGRAPHICAL INFORMATION

                                    
       NAME:                                                Prof. Tapas K. Kundu
       PRESENT POSITION:                      Associate Professor
       ADDRESS:                                         Transcription and Disease Lab
                                                                    Molecular Biology and Genetics Unit
                                                                    JNCASR, Jakkur
                                                                    Bangalore-560064
       PHONE:                                              080- 22082840, 080-22082841
       FAX:                                                    +91-80-22082766

   ACADEMIC QUALIFICATION:         

Degree                                            Year                                                  University
BSC (AG) (Hons)                       1982-86                                   Bidhan Chandra Agricultural University
                                                                                                    West Benagl, INDIA
M.Sc. (Biochemistry)                 1987-89                                   Univesity of Agricultutal sciences, GKVK, Bangalore.
                                                                                                     Karnataka, INDIA
Ph.D                                            1990-95                                   Department of Biochemistry, Indian Institute                                                                                                      of Science, Bangalore, INDIA

 POSITIONS HELD (Chronological order)

University/ Institute                                            Year                                   Position Held
Department of Molecular Genetics,                  1995-96                       Visiting Foriegn Research Associate
National Institue of Genetics, Mahima,
Japan
Laboratory of Biochemistry and                        1996-99                       Post Doctoral Fellow
Molecular Biology,
Rockefeller University, USA
Molecular Biology and Genetics                 1999 to october 2005        Assistant Professor
Unit, JNCASR, INDIA                                 Oct. 2005 to present        Associate Professor

   HONORS AND AWARDS

   1. 1990, Gold Medal for securing first position in M.Sc. India.
   2. 1990-1995, JRF and SRF from UGC, India.
   3. 1993, International Council of Scientific Union Award, India.
   4. 1995, GIRI MEMORIAL AWARD for best thesis in Biochemistry, IISc. India.
   5. 1996, COE Visiting Scientist fellowship from MONBUSHO, Government of Japan.
   6. 2001, International Union Against Cancer, Fellowship, Switzerland.
   7. 2001, Human Frontier Science Programme Organization, Fellowship, France.
   8. 2003, Selected for Indo-Japan Cooperative Science Programme (IJCSP).
   9. Nominated member of American Chemical Society (2001-    )
   10. Fellow of the UICC (International Union Against Cancer) (2001- 02)
   11. Nominated member of American Society for Molecular Biology and Biochemistry (ASMB)(2003)
   12. Elected member of Guha Research Conferance (GRC)
   13. Member of American Society of Microbiology
   14. NAtional Bioscience Award for Carrier Development from Dept. of Biotechnology, Govt. of India
   15.
Fellow of the UICC (International Union Against Cancer) (2005- 06)

   16. Shanti Swarup Bhatnagar Award for Biological Sciences for the year 2005-06 from Council of Scientific and Industrial     Research, Govt. of India

 

   

List of Selected Publications:

1. Kundu,T.K., and Rao,M.R.S. 1996. Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2. Biochemistry. 35 (49): 15626-15632.
 

2. Kundu,T.K., Kusano, S. and Ishihama, A. 1997. Promoter selectivity of Escherichia coli RNA polymerases F holoenzyme involved in transcription of flagellar and chemotaxis genes. J. Bacteriol. 179(13): 4264-4269.

3. Martinez, E., Kundu,T.K., Fu, J. and Roeder, R.G. 1998. A human SPT3- TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. J. Biol. Chem. 273(37): 23781-23785.

4. Kundu, T.K.,* and Rao, M.R.S. 1999. CpG Islands in chromatin organization and gene expression. J. Biochem. 125: 217-222.

5. Kundu,T.K., Wang, Z. and Roeder, R.G. 1999. Human TFIIIC relieves chromatin-mediated repression of RNA polymerase III transcription and contains an intrinsic histone acetyltransferase activity. Mol. Cell. Biol. 19(2): 1605-1615.

6. Hsieh, Y-J^., Kundu, T. K.,^ Wang, Z., Kovelman, R., and    Roeder, R. G. 1999. The TFIIIC90 subunit of TFIIIC interacts with multiple components of RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. Mol. Cell. Biol. 19(11): 7697-7704.

7. Lau,O.D.,^ Kundu,T.K.,^ Soccio,R.E., Khalil, E.M., Vassilev,A., Nakatani,Y., Roeder,R.G. and Cole, P.A. 2000. HATs off: Selective synthetic inhibitors of the histone acetyltransferases  p300 and PCAF.  Mol. Cell. 5, 589-595.

8. Kundu,T.K.,^ Palhan, V., ^ Wang, Z., An,W., Cole, P.A. and Roeder, R.G. 2000. Activator dependent transcription from a chromatin template involving targeted histone acetylation by p300. Mol. Cell. 6, 551-561.

9. Kumar, P. B. R., Swaminathan, V., Banerjee, S., and Kundu, T. K.* 2001. p300-Mediated acetylation of human transcriptional coactivator is inhibited by phosphorylation. J. Biol. Chem. 276 (20), 16804-16809.

10. Martinez, E., Palhan, VB, Tjeruberg A, Laymer, ES, Gamper AM, Kundu, T. K. , Chait BT and Roeder R. G.  2001.  Human   STAGA complex induce chromatin mediated transcription and DNA repair activity. Mol.Cell.Biol  21 (20) 6782-6795.

11.  Kar S, Sakaguchi K, Shimohigashi Y, Samaddar S, Banerjee R , Basu  G,  Swaminathan V , Kundu  T.K   and Roy S 2002. Effect of Phosphorylation on the Structure and Fold of Transactivation domain of p53  J.Biol.Chem. 277, 15579-15585.

12. Karanam Balasubramanyam, V. Swaminathan, Anupama Ranganathan, and Kundu T.K.* (2003). Small Molecule Modulators of Histone Acetyltransferase p300. J. Biol. Chem. 278, 19134-19140.

13.  Banerjee, S., and Kundu, T.K.* (2003). The acidic C-terminal domain and A-box of HMG-1 regulates p53-mediated transcription. Nucleic Acids Research, 31, 3236-  3247.

14. Banerjee, S., Kumar, P. B. R. and Kundu, T.K.* (2004). General Transcriptional Coactivator PC4 activates p53 function. Mol. Cell. Biol, 24(5): 2052-62

15. Balasubramanyam K, Altaf M, Varier RA, Swaminathan V, Ravindran A, Sadhale PP,  and Kundu TK. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem. 2004 Aug 6;279(32):33716-26.

 16. Radhika A. Varier., V. Swaminathan., Karanam Balasubramanyam., and Tapas. K.Kundu.* (2004). Implications of small molecule activator and inhibitors of histone acetyltransferases in chromatin therapy. Biochem. Pharmacol. Sep 15;68(6):1215-20.

17.Balasubramanyam K, Varier RA, Altaf M, Swaminathan V, Siddappa NB, Ranga U, Kundu TK* (2004). Curcumin, a novel p300/CBP specific inhibitor of acetyltransferase, represses the acetylation of histones/nonhistone proteins and HAT dependent chromatin transcription. J. Biol. Chem.Aug 6;279(32):33716-26

18.Subhashini Sadasivam, Sanjeev Gupta, Vegesna Radha, Kiran Batta, Kundu T.K. and Ghanshyam Swarup. Caspase-1 activator 1paf is a p53- inducible gene involved in apoptosis. Oncogene. 2005 Jan 20; 24(4):627-36

19. Davidson SM, Townsend PA, Carroll C, Yurek-George A, Balasubramanyam K,
Kundu TK, Stephanou A, Packham G, Ganesan A, Latchman DS. The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. Chembiochem. 2005 Jan; 6(1):162-70.

20. Das C and Kundu TK (2005) Transcriptional regulation by the acetylation of nonhistone proteins in humans- a new target for therapeutics. IUBMB Life; 57(3): 137-49

 

21. Swaminathan V, Kishore HA, Febitha KK and Kundu TK (2005), Human Histone Chaperone Nucleophosmin Enhances Acetylation Dependant Chromatin Transcription. Mol.Cell.Biol. 25(17): 7534-45.

 

22. Varier, RA and Kundu, TK. (2005) Chromatin Modifications (Acetylation/ Deacetylation/ Methylation) as new targets for HIV therapy. Curr.Pharm.Des. (In press)

23. Shravanthi Rampalli, L.Pavitha, Altaf Bhatt, Tapas K. Kundu, and Samit Chattopadhay. (2005) Tumor Suppressor SMAR1 mediates Cyclin D1 Repression by Recruitment of the SIN3/Histone Deacetylase 1 complex. Mol.Cell.Biol. 25(19): 8415-29.

Patents:

1. Cole, P.A., Raymond E. Soccio, Lau,O.D., Soccio,R.E., Khalil,E.M.,  Kundu, T.K., Roeder R. G., and 1999. Inhibitors of histone acetyltransferases (HATs) and uses thereof.  No.: US 6,369,030 B1

2. Karanam Balasubramanyam, Venkatesh Swaminathan, Tapas K. Kundu* Modulators (inhibitors/activators) of histone acetyltransferases (Indian patent application No 925/Mas/2002) filed on 12/12/2002 at Chennai (India) patent office.

3. Karanam Balasubramanyam and Tapas K Kundu*  (2003). Polyisoprenylated benzophenones and their isomers as inhibitors of Histone acetyltransferases and uses thereof. No:  929/CHE/2003.

4. Balasubramanyam, K., Radhika, A.V., Altaf, M., Swaminathan, V., and Kundu, T.K.* (2004). Use of curcuminoids as inhibitors of histone acetyltransferases (HATs). No:  544/CHE/2004.

 

5. Febitha, K. K., Radhika A. Varier, Chandrima Das and Kundu, T.K. (2004). A set of highly specific polyclonal antibodies of individual core histones and its uses thereof. No: 1253/ CHE/2004

 

 * Corresponding author
 ^ Equal contribution
 
 
                                                                                                                                                                       
  

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