The laboratory has been examining various aspects of the biochemistry of the enzyme HGPRT. Studies have included elucidation of the molecular basis of substrate specificity, examination of the role of peptide bond isomerization in catalysis and substrate distortions upon binding with the enzyme among many others.
a.Distortion in guanine at the active site of HGPRT – depicted on a schematic free-energy profile.
b. Coupled events of ligand induced isomerization and oligomerization in catalysis by PfHGXPRT
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