Chromatin Dynamics Regulated by non-histone chromatin proteins:

Our group has discovered that the highly abundant, multifunctional nuclear protein, PC4 is a bonafide chromatin component involved in the chromatin compaction and thereby genome organization and transcription regulation. Our group has generated PC4 knockdown stable cell line and found that PC4 is indeed involved in genome stability. Interestingly, in a large number of breast cancer samples, PC4 expression was found to be down-regulated. Total knockout of PC4 is embryonic lethal. Presently, our group is working on organ-specific conditional knockout mice.

• Das C, Hizume K, Batta K, Kumar BR, Gadad SS, Ganguly S, Lorain S, Verreault A, Sadhale PP, Takeyasu K, Kundu TK*. (2006) Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation. Mol Cell Biol:26(22):8303-15.

• Das C, Gadad SS, and Kundu TK*. (2010) Human Positive coactivator 4 controls Heterochrominization and silencing of neural gene expression interacting with REST/NRSF and CoREST. J Mol Biol: 397(1): 1-12

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