Nanobiotechnology approach for targeted
therapy
In collaboration with the CPMU, JNCASR we are actively working in the area
of nanobiotechnology. The major emphasis has been given to the possible
utilization of our recently discovered carbon nanospheres. The mechanism of
its ability to cross the blood-brain barrier, delivery of the HAT activator
molecule in the mammalian brain and targeted delivery of anti-neoplastic
therapeutics in the solid tumor targeting the epigenetic modifications are
the major focus of our laboratory. Recently, we have successfully conjugated
a histone acetyltransferase activator with the CSP and could target it to
mice brain. The conjugated molecule could induce histone hyperacetylation in
hippocampus of mice brain thereby induces neurogenesis and long term spatial
memory formation.
CSP-TTK21 induces histone hyperacetylation in cell lines and
hippocampus of mice brain
