सतह-संवर्धित रामन स्पेक्ट्रोस्कोपी ऑटोफैजिक स्थितियों के तहत एक्स्ट्रासेलुलर वेसिकल्स को अलग करने के उपकरण के रूप में - रोग निदान के लिए एक मार्कर

Extracellular vesicles (EVs) laden with lipids, proteins, DNA, and micro-RNAs play important biological functions in intercellular communication and have pivotal roles in pathophysiological conditions. Characterization of the EVs has always been a multistep process involving large volumes, and they are heterogeneous in size and properties. A multitude of approaches is used to distinguish the EVs. Here, we report simple citrate reduced silver nanoparticles assisted surface-enhanced Raman spectroscopy (SERS) as a tool to distinguish EVs extracted from several cell lines isolated under autophagic conditions (nitrogen starvation).

Chalapathi, D., Padmanabhan, S., Manjithaya, R., & Narayana, C. (2020). Surface-Enhanced Raman Spectroscopy as a Tool for Distinguishing Extracellular Vesicles under Autophagic Conditions: A Marker for Disease Diagnostics. Journal of Physical Chemistry B, 124(48), 10952–10960. https://doi.org/10.1021/acs.jpcb.0c06910