प्लाज़्मोडियम में न्यूक्लियोटाइड और एनर्जी मेटाबॉलिज़्म के बीच संकरवार्ता

The adenylate arm of purine nucleotide synthesis generates the TCA cycle intermediate fumarate. In P. falciparum, during its intraerythrocytic stages the cellular requirement of ATP is met mainly through glycolysis with a very weak flux through the TCA cycle. In this context, we have examined the cellular fate of fumarate generated as a by-product of AMP synthesis and characterized fumarate hydratase, the enzyme involved in fumarate metabolism.