We are a group of chemists and enthusiasts of non-covalent interactions
working at the interface of chemistry and biology and trying to contribute to
the advancement of natural sciences. The central theme of our research is
molecular recognition in synthetic systems: from fundamental studies to
applications in biology and materials. Our primary design principles rely on
two types of synthetic scaffolds, macrocyclic host-guest receptors, and
nucleic acid scaffolds. We are working on combining these supramolecular
systems with the biological interface to develop various novel technologies
with relevance to both fundamental and medical research. Examples include
biorthogonal imaging and sensing, methods for super-resolution imaging, and
new approaches for delivery and activation of therapeutic materials.
The research theme of Agasti lab at the interface of chemistry and
biology
1. Som, A.; Pahwa, M.; Bawari, S.; Saha, N. D.; Sasmal, R.; Bosco, M.
S.; Mondal, J.; Agasti, S. S., Multiplexed optical barcoding of cells
via photochemical programming of bioorthogonal host-guest recognition.
Chem. Sci.
2021,
12 (15), 5484-5494.