A genetically-encoded fluorescence-based reporter to spatiotemporally investigate mannose-6-phosphate pathway

Recent research has highlighted the relevance of mannose-6-phosphate (M6P) pathway-mediated trafficking of lysosomal hydrolases in health and disease. We have developed a new genetically-encoded fluorescence-based reporter to spatiotemporally track M6P pathway. Functionality and robustness of the reporter were validated under different physiological and pathophysiological conditions and also across different cell types.

We have developed a new genetically-encoded fluorescence-based reporter to spatiotemporally track M6P pathway. Functionality and robustness of the reporter were validated under different physiological and pathophysiological conditions and also across different cell types.

Bhat, M., Nambiar, A., Edakkandiyil, L., Abraham, I. M., Sen, R., Negi, M., & Manjithaya, R. (2024). A genetically-encoded fluorescence-based reporter to spatiotemporally investigate mannose-6-phosphate pathway. Molecular Biology of the Cell, mbc-E23.