Histone Chaperones in the regulation of transcription and thereby diseases

Histone Chaperones in the regulation of transcription and thereby diseases

Our group is working on the human histone chaperone NPM1 and have found that it is a regulator of RNA polymerase II-driven chromatin transcription in an acetylation-dependent manner. We have shown that NPM1 was over-expressed and hyperacetylated in oral cancer. We have also found that NPM1 is a positive regulator of p300 autoacetylation. The mechanisms of transcription regulation by NPM1 and its gene specificity are being investigated now.

Prof. Tapas K Kundu, Dr. Swaminathan Venkatesh, Dr. Shrikanth Gadad, Dr. Parijat Senapati

Swaminathan V, Kishore AH, Febitha KK, Kundu TK*. (2005) Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription. Mol Cell Biol: 25(19): 7534-45

• Shandilya J, Swaminathan V, Gadad SS, Choudhari R, Kodaganur GS, Kundu TK*. (2009) Acetylated NPM1 localizes in the Nucleoplasm and Regulates Transcriptional Activation of Genes Implicated in Oral Cancer Manifestation. Mol.Cell.Biol:29(18):5115-27

Submitted by tapas on 17/02/2021.