Histone Chaperones in the regulation of transcription and thereby diseases

Our group is working on the human histone chaperone NPM1 and have found that it is a regulator of RNA polymerase II-driven chromatin transcription in an acetylation-dependent manner. We have shown that NPM1 was over-expressed and hyperacetylated in oral cancer. We have also found that NPM1 is a positive regulator of p300 autoacetylation. The mechanisms of transcription regulation by NPM1 and its gene specificity are being investigated now.

Swaminathan V, Kishore AH, Febitha KK, Kundu TK*. (2005) Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription. Mol Cell Biol: 25(19): 7534-45

• Shandilya J, Swaminathan V, Gadad SS, Choudhari R, Kodaganur GS, Kundu TK*. (2009) Acetylated NPM1 localizes in the Nucleoplasm and Regulates Transcriptional Activation of Genes Implicated in Oral Cancer Manifestation. Mol.Cell.Biol:29(18):5115-27

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