एपिजेनेटिक परिघटना को समझने के लिए रासायनिक जैविक दृष्टिकोण
Chemical biology approach to understand epigenetic phenomena
Work in our laboratory has immensely contributed to the area of modulators of
chromatin modifying enzymes. These modulators have helped in understanding the
epigenetic phenomena underlying several physiological and pathophysiological
processes. The present focus of the laboratory is to find out the non-ATP
analog inhibitors of Aurora Kinases, more potent small molecule modulators of
Histone Acetyltransferases and Arginine Methyltransferases from natural
sources.recently, we have identified a specific inhibitor of histone
acetyltransferase PCAF by employing which the role of PCAF acetylation in
muscle differentiation is being investigated. In another interesting finding,
we have isolated a very specific inhibitor of histone arginine
methyltransferase PRMT4/CARM1. Using this inhibitor as a synthon, we have
synthesized a few novel inhibitor of arginine methyltransferase which may hane
some therapeutic importance.