टी गोविंदराजू

Fundamental Chemistry of Biomolecules to Tackle Human Diseases

Our lab is effectively using tools from organic synthesis, biophysics, chemistry and chemical biology in tackling two classes of challenging problems currently relevant to human health and society:

A. Our work on disease amyloids has led to the development of novel diagnostics of Alzheimer’s Disease (AD) that selectively detect AD and differentiate it from other neurodegenerative diseases, and a novel drug candidate molecule (TGR63) that has been demonstrated to be effective in notable reduction of amyloid burden in the AD brain and reverse cognitive decline in animal models and is now under clinical studies in collaboration with a pharmaceutical company with a promise to treat AD in humans. 

B. Our work on functional amyloids led to the development of silk-derived formulations for sustained in vivo insulin delivery, diabetic wound healing, skeletal muscles and neuronal tissue engineering, value addition to the sericulture industry and farmers. This work further inspired the concept of Molecular Architectonics which integrates the realms of molecules and derived nano-scale molecular architectures into functional biomaterials.