Synthesis of different materials by high temperature solid state method.

Many biologically important small molecules including acylhydrazides and N,N'-diacylhydrazines contain a (CO)-NR1-NR2-R moiety (where R can be another CO, R1 and R2 can be H, alkyl or aryl groups). In addition, peptidomimetic oligomers such as azapeptides and azatides contain CO-NR1-NR2-CO units embedded in their structure. The conformational properties of these molecules are often described  based on the repulsion between their nitrogen lone pairs, which is inadequate.

n → π* is an important noncovalent interaction found in many small molecules and proteins. In recent years, importance of n → π* interaction was described in transition metal carbonyl complexes, dynamic covalent chemistry (DCC), transition state stabilization, enzyme catalysis and molecular rotors.

• Conformational Dynamics of Proteins
• Mechanisms of Product Release from Enzyme
• Interfacial activation of Lipases
• Thermostability of proteins
• Structure and Dynamics of Solvent-Free Protein Liquids

• Mechanisms of Supramolecular Aggregation
• Pathway Complexities in Supramolecular Aggregation