Nanobiotechnology approach for targeted therapy

Nanobiotechnology approach for targeted therapy
In collaboration with the CPMU, JNCASR we are actively working in the area of nanobiotechnology. The major emphasis has been given to the possible utilization of our recently discovered carbon nanospheres. The mechanism of its ability to cross the blood-brain barrier, delivery of the HAT activator molecule in the mammalian brain and targeted delivery of anti-neoplastic therapeutics in the solid tumor targeting the epigenetic modifications are the major focus of our laboratory. Recently, we have successfully conjugated a histone acetyltransferase activator with the CSP and could target it to mice brain. The conjugated molecule could induce histone hyperacetylation in hippocampus of mice brain thereby induces neurogenesis and long term spatial memory formation.

CSP-TTK21 induces histone hyperacetylation in cell lines and hippocampus of mice brain