After nearly a decade of research, scientists from the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, have developed a molecule that could be a potential drug candidate to halt or cure the leading cause of dementia (70-80 per cent) worldwide. The research has been published in the journal Advanced Therapeutics.
As per the study, Dr T Govindaraju, Professor, JNCASR, and his team designed and synthesised molecules which can reduce the toxicity of-amyloid peptide—that accumulates in the central nervous system. “The molecule, called TGR63, can rescue neuronal cells from amyloid toxicity. We saw that the molecule helped in reducing the clumping and slowly reversing the cognitive decline,” claimed Dr Govindaraju.
Publication details:
Samanta, S., Rajasekhar, K., Ramesh, M., Murugan, N.A., Alam, S., Shah, D., Clement, J.P. and Govindaraju, T. (2021), Naphthalene Monoimide Derivative Ameliorates Amyloid Burden and Cognitive Decline in a Transgenic Mouse Model of Alzheimer's Disease. Adv. Therap. 2000225. https://doi.org/10.1002/adtp.202000225
News reported by:
