A Feature Article was published on invitation by our group in RSC Chemical Communications journal. In this article, we share our journey with the Gram-positive antibiotic Vancomycin, and efforts to tackle Vancomycin-resistant superbugs through the development of semisynthetic vancomycin analogues. The next-generation glycopeptides developed by our group over the past decades tackle both Gram-positive and Gram-negative superbugs, and their non-inherited forms of resistance such as biofilms, stationary phase and persister cells, intracellular infections etc.
The feature article covers work by two illustrious young researchers Dr. Venkateswarlu Yarlagadda and Dr. Paramita Sarkar from our group. We also describe existing problems and chart the potential directions for future investigations in glycopeptide research.
The article is co-authored by Mr. Yash Acharya, Ms. Geetika Dhanda, Dr. Paramita Sarkar and Prof. Jayanta Haldar.
© 2021, JNCASR, Jakkur, Bangalore, India