Organic and supramolecular chemistry

Organic and supramolecular chemistry

We are a group of chemists and enthusiasts of non-covalent interactions working at the interface of chemistry and biology and trying to contribute to the advancement of natural sciences. The central theme of our research is molecular recognition in synthetic systems: from fundamental studies to applications in biology and materials. Our primary design principles rely on two types of synthetic scaffolds, macrocyclic host-guest receptors, and nucleic acid scaffolds. We are working on combining these supramolecular systems with the biological interface to develop various novel technologies with relevance to both fundamental and medical research. Examples include biorthogonal imaging and sensing, methods for super-resolution imaging, and new approaches for delivery and activation of therapeutic materials.

The research theme of Agasti lab at the interface of chemistry and biology

1. Som, A.; Pahwa, M.; Bawari, S.; Saha, N. D.; Sasmal, R.; Bosco, M. S.; Mondal, J.; Agasti, S. S., Multiplexed optical barcoding of cells via photochemical programming of bioorthogonal host-guest recognition. Chem. Sci. 2021, 12 (15), 5484-5494.