Role of p300/CBP-mediated acetylation in neurodevelopmental (autism), Neurodegenerative disorders, and Depression
Epigenetic regulatory mechanisms, including DNA methylation, chromatin remodelling, histone modification, and microRNA expression, play critical roles in neurogenesis through spatiotemporal gene regulation. Any perturbation in these epigenetic modifications can contribute to neurodevelopmental and neurodegenerative disorders. As dysregulation of histone acetylation machinery is quite well established in the pathophysiology of some neurological disorders, we are looking at the p300/CBP mediated acetylation in neurodevelopmental (autism), neuropsychiatric (depression) and neurodegenerative (Parkinson's and Huntington's) conditions. By employing the p300/CBP KAT activity-specific activator, our group is looking at the effects on LTP deficit, memory and behavioural phenotypes and if it ameliorates the molecular and behavioural deficits in animal and cellular models. We also are looking gene expression levels impaired by the disease and subsequent KAT activator treatment.
