Specific KAT activator: implications in Nano-Biotechnology and Neurodegenerative Diseases

Our group is actively working in the area of nanobiotechnology in collaboration with other groups. The major emphasis has been given to the possible utilization of their recently discovered carbon nanospheres. The mechanism of its ability to cross the blood-brain barrier, delivery of the HAT activator molecule in the mammalian brain and targeted delivery of anti-neoplastic therapeutics in the solid tumor targeting the epigenetic modifications are the major focus of our laboratory. We have successfully conjugated a histone acetyltransferase activator with the CSP and could target it to mice brain. The conjugated molecule could induce histone hyperacetylation in hippocampus of mice brain thereby inducing neurogenesis and long term spatial memory formation. Recently we have shown that indeed the specific activation of p300/CBP could result in almost complete recovery of memory in the neurodegenerative disease model. This activation could also dramatically lead to repairing of spinal injury in mice and rat.