The principal focus of my work has been to identify the emerging variants of HIV-1 subtype C in the Indian population and to understand the latency establishing and reversal properties of these strains. In a longitudinal clinical study performed in collaboration with four hospitals in India, we have studied multiple prognostic markers and viral reservoir to understand the pathogenesis and disease progression due to the changes in the transcription factor binding sites (TFBS) in the promoter of these emerging variants.
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Sreshtha Pal pursuing Ph.D.
Random fluctuations in gene expression are known to critically influence gene regulatory circuits in driving fate decisions. I am trying to understand how HIV-1 promoter architecture and associated positive feedback circuit modulates gene expression noise hence driving viral fate-switch.
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Swarnima Mishra pursuing Ph.D.
I work on understanding the correlation of HIV promoter (LTR) variants with viral reservoir characteristics and its modulation in context of disease progression.
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Buch Hrimkar Bhargav pursuing Ph.D.
Bsc. in Biochemistry from St. Xavier's College, Ahmedabad, Gujarat
MSc. in Biochemistry from Institute of Science, Nirma University, Ahmedabad, Gujarat
I am working on elucidating the biological significance of ‘PTAP’ motif duplication in Gag polyprotein of HIV-1C. My work involves characterization of characterization of the nature of the PTAP duplication in HIV-1C and to understand how the duplication plays a role in propagation of the viral variant.
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Chhavi Saini pursuing Ph.D. (Biological Sciences)
Function of Tat is very well established for active viral transcription, by recruiting components of host transcriptional machinery. Recent findings from our laboratory demonstrating a positive correlation between the transcriptional strength of the viral promoter and the rate of latency establishment in HIV-1 allude to a direct role for Tat in latency establishment. In other words, Tat may demonstrate context-dependent and diametrically opposite effects on viral transcription, activating, or suppressing viral gene expression. My work is to find post-translational modifications of Tat at different phases of viral gene expression which could determine the positive or negative influence on viral transcription.
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Shobith Suresh pursuing Ph.D.
Educational Background :
Msc in Virology from Amity Institute Of Virology & Immunology, Amity University, Uttar Pradesh.
BSc in Microbiology from Kannur University, Kerala.
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Arun Panchapakesan pursuing Ph.D.
I work on the molecular properties of HIV-1C Reverse Transcriptase that enable the virus to duplicate sequence motifs of biological significance.