Activation of p300/CBP by specific small molecule activator-induced neurogenesis and memory formation

In collaboration with our material chemistry group, we have found that the glucose-derived carbon nanosphere (CSP) is capable of crossing the blood-brain barrier (Selvi BR et al.,2008) and can deliver small molecule compounds to the brain, administrated either by IP or oral (Singh AK et al., 2024). We have successfully conjugated the histone acetyltransferase activator, TTK21, with CSP and could target it to the mouse brain. The conjugated molecule (CSP-TTK21) could induce histone hyperacetylation in the mice hippocampus, thereby inducing neurogenesis and long-term spatial memory formation (Chatterjee S et al., 2013). Recently, we showed that the specific activation of p300/CBP could result in an almost complete memory recovery in the neurodegenerative disease model (Chatterjee et al., 2018) (Singh AK et al., 2022). This activation also leads to a dramatic repair of spinal cord injury (Hutson et al., 2019) and improvement of behavioral deficits in autism ((Singh AK et al., 2025). We have also shown recently that CSP-TTK21 mediated p300 autoacetylation and its effects in neurogenesis (Smitha AS et al., 2024).

Specific KAT activator: Implications in Neurological Disorders

1. Selvi BR, Jagadeesan D, Suma BS, et al.

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